Models for biological phosphoryl transfer
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چکیده
منابع مشابه
Models for biological phosphoryl transfer.
Quantifying the rate of phosphate monoester dianion hydrolysis under physiological conditions has implications for designing transition state mimics and understanding how catalysis is facilitated. Catalysis is energetically most efficient if the mechanistic pathway in solution is stabilised. Monoesters are believed to have a "dissociative" transition state that has little bonding to the nucleop...
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Phosphoryl-transfer reactions are central to biology. These reactions also have some of the slowest nonenzymatic rates and thus require enormous rate accelerations from biological catalysts. Despite the central importance of phosphoryl transfer and the fascinating catalytic challenges it presents, substantial confusion persists about the properties of these reactions. This confusion exists desp...
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The high resolution crystal structures of two interacting proteins from the phosphoenolpyruvate:sugar phosphotransferase system, the histidine-containing phosphocarrier protein (HPr) and the IIA domain of glucose permease (IIA(Glc)) from Bacillus subtilis, provide the basis for modeling the transient binary complex formed during the phosphoryl group transfer. The complementarity of the interact...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
سال: 2004
ISSN: 1570-9639
DOI: 10.1016/j.bbapap.2003.11.031